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PEA guards towards bacterial an infection by using innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.1 mg/kg overall body bodyweight prolonged survival fee and minimized neuro-inflammation within an aged murine bacterial meningitis model, during t
PEA safeguards in opposition to bacterial infection by way of innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA in a dose of 0.one mg/kg system fat prolonged survival fee and reduced neuro-inflammation within an aged murine bacterial meningitis model, during the
2015). These experiments, taken alongside one another, suggest that, although a direct activation of GPR55 or PPAR?α takes place, PEA can produce its anti?inflammatory action in the intestine also by way of oblique activation of CB1 and CB2 receptors, probably as a consequence of the flexi
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This receptor also binds to opioid peptides, b